Multiple Sclerosis

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  • Constant monitoring needed for new MS treatments

    Multiple Sclerosis News From Medical News Today
    3 Aug 2015 | 4:00 am
    Advances in the treatment of multiple sclerosis have been good news for patients, but side- effects and risks mean that active management strategy and constant monitoring are essential, advise the...
  • Our elegant brain: Motor learning in the fast lane

    Multiple Sclerosis News From Medical News Today
    4 Aug 2015 | 3:00 am
    Small group of neurons adjust to difference between expected and actual sensory informationIt takes a surprisingly small cluster of brain cells deep within the cerebellum to learn how to serve a...
  • Somatosensory Evoked Potential

    ThisIsMS - News
    kitty2015
    4 Aug 2015 | 5:16 am
    General Discussion Statistics : 2 Post || 37 Views Post by kitty2015
  • Itchiness as an MS Symptom

    Brass and Ivory: Life with MS and RA
    16 Jul 2015 | 6:40 am
    When pruritus occurs as a symptom of multiple sclerosis, it is similar to other neurologic sensations - pins and needles, burning, stabbing, or tearing pain - known as dysesthesias. The itching with MS is often paroxysmal (coming on suddenly with great intensity) but temporary in nature and lasting anywhere from a couple of seconds to minutes. It can even seem to get worse the more you scratch.Heat triggers pruritus for some people with MS and for others, it seems to be related to movement or tactile stimulation. For some reason, the itching often occurs at night with an intensity that has…
  • NEDA-5: Neurofilaments

    Multiple Sclerosis Research
    Neuro Doc Gnanapavan
    4 Aug 2015 | 1:00 am
    NEDA or 'No Evidence of Disease Activity' currently uses 4 parameters that are routinely collected in contemporary clinical trials:Relapse activityDisability progressionMRI activityMRI atrophyNEDA-4NEDA has largely come into fruition with the introduction of highly active therapies, which for the first time allow us to achieve disease remission in MS. These therapies have set the benchmark, and as they grow in number so do our treatment expectations. And here starts the evolution in our definition of MS treatment strategies.The Holy Grail of MS treatment strategy will always be in my books…
 
 
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    MS-UK Latest MS News

  • Mitochondria ‘may play role in MS progression’

    9 Jul 2015 | 7:44 am
    Recent attention to the role of mitochondria in the cause of multiple sclerosis suggests mitochondrial defects and mitochondrial structural and functional changes may contribute to the condition. Researchers studying mitochondria in multiple sclerosis believe abnormalities in mitochondrial dynamics impact cellular pathways such as inflammation and demyelination, ultimately impacting patients with multiple sclerosis.....
  • Breakdown in brain communication discovered

    8 Jul 2015 | 11:22 am
    New findings published in Neuropsychology reveal decreased connectivity between network-specific brain regions are to blame for the central deficit common to the various cognitive changes associated with multiple sclerosis....
  • Bacteria “biofilm” mystery investigated

    8 Jul 2015 | 10:36 am
    Lupus, multiple sclerosis, and type-1 diabetes are among more than a score of diseases in which the immune system attacks the body it was designed to defend. But just why the immune system begins its misdirected assault has remained a mystery.....
  • Researchers find key neuropathic pain trigger

    8 Jul 2015 | 8:41 am
    Scientists at the University of California, Davis, have identified a key mechanism in neuropathic pain. The discovery could benefit millions of patients with chronic pain from trauma, diabetes, shingles, multiple sclerosis or other conditions that cause nerve damage....
  • American Society funds grant to explore new MS pathology model

    2 Jul 2015 | 12:32 pm
    America’s National Multiple Sclerosis Society has provided a grant to a Wayne State University School of Medicine professor to explore a new model of MS pathology.....
 
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    Blindbeard's Multiple Sclerosis Blog

  • Tecfidera; Notes From The Lobster Pot

    24 Jul 2015 | 8:10 am
    Multiple Sclerosis sucks, but these MS disease modifying drugs are the bane of my existence. I started Tecfidera in April after trying and failing the 3 times a week Copaxone. I swear I am more old injection site lumps and dips than woman. It makes those shots such a hoot I wasn't sure how much more fun I could handle in my life and found myself "forgetting", skipping, and finally downright unwilling to do it to myself anymore. (Also I think the 3x a week Copaxone stings more.) As much as I would love to -- metaphorically speaking -- skip off into the sunset DMD free forever, I…
  • Guide For The Newly Diagnosed: Pay No Attention To The Man Behind The Curtain

    13 Mar 2014 | 12:50 pm
    And that man is usually a member of the general public spouting tired cliches mostly found on Facebook posts with cute kittens. You know, the kind of sh*t you see and think, "that is true... Ha ha! My ex slipped on the ice and broke his fat ass! That's the most uplifting post I have ever seen on here!" You are going to hear a criminal amount of stupid crap, useless platitudes and general bad advice. Refer to the good advice in the title of this post. Depending on the source and my mood I have different ways of handling these sages.The Slow BlinkSome one just told you, "None of us knows what…
  • Guide For The Newly Diagnosed: The Answer

    24 Feb 2014 | 10:07 am
    This is an idea that I have been mulling over for awhile now. Next month will be my 9 year anniversary (cue the circus music) of being diagnosed and I have learned an obscene amount about MS since then. A truly tantalizing ton from tomes, and a lewdly large lump of life lessons. Think of how many little nuggets that we have learned the all too often (very) hard way, and think of how many things we would have liked someone to tell us when we were newly diagnosed. So, because where I am at in my disease course is a total snoregasm (from Bob's Burgers, I wish I'd made that word up!), I'm going…
  • Things I Have Learned From Courtney Stodden

    14 Nov 2013 | 12:43 pm
    I have enjoyed Courtney Stodden for quite some time now. It started with an interview where she writhed around on a couch like she was on the verge of a heaving orgasm. That might have been the end of it, but she was a very determined young woman who went to a pumpkin patch to reenact the Kama Sutra with her sugar daddy for all the kids to see. Unfortunately, all the women were too jealous of how much their husbands were liking it, complained that she was too "sexy", and she was tossed out of there. The problem is that ever since she broke up with Doug, she has become a predictable bore. It…
  • Things I'm Tired Of

    25 Oct 2013 | 5:33 pm
    In order1. Cluster HeadachesThese are the worst thing I have ever experienced. Period. Period again. Bar none, NONE. They make MS look like a fun and lighthearted day in the park. I am so tired of being in the grip of them, of being scared of getting one while in public, of being a prisoner to them. I'm taking a new medicine now that has really helped bring down the severity of the attacks. I still get a few breakthroughs that bring me to my knees, but for the most part it is helping. God am I tired of clusters.2. My ExThat man is going to be the death of me. And if that is the case, I better…
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    Life With Multiple Sclerosis

  • Taking Advantage of the Good Days (or Good Moments) With MS

    Trevis Gleason
    28 Jul 2015 | 8:07 am
    We haven’t had much of a summer in my little corner of the North Atlantic. Though many parts of America are scorching this year, and many areas of Europe are sweltering, I think we’ve only broken the 60 degrees F mark once… and I was on a train to Dublin that day. The past couple of weeks have been windy, cold, and pissing down rain for most of the daylight hours. Just this morning a national radio presenter asked a representative from Met Éireann, the Irish National Meteorological Service, “What the hell is going on?!” I tell everyone: “You don’t come to Ireland for the…
  • Why the Americans With Disabilities Act Wouldn’t Pass Today

    Trevis Gleason
    23 Jul 2015 | 8:15 am
    By now, most of us will have heard one news piece or another about the 25th anniversary of the Americans with Disabilities Act (ADA). Twenty-five years doesn’t seem like that long ago, really. In fact, I remember writing a blog on the 20th anniversary of the bill’s signing into law. I guess we’ve been at this a while now. A video of President Obama talking about his father-in-law’s MS during a White House event marking the ADA milestone is even making the rounds. I’ve just started reading Lennard J. Davis’ book Enabling Acts: The Hidden Story of How the Americans With…
  • What’s Popping Out of Your Multiple Sclerosis Clown Car?

    Trevis Gleason
    20 Jul 2015 | 2:01 pm
    Coulrophobia is the term for an abnormal or morbid fear of clowns. Though some of my dear friends have been clowns, I also know people who are completely creeped out by them. As the ringmasters of our individual three-ring circuses of life, we all know what it’s like to try to keep the show running in a professional manner when some “clown” of an MS symptom stages an entrance. I sometimes feel like I’ve got a lion tamer cracking a deadline whip in one ring, a bear balancing a ball of social obligations in a second, while some other aspect of my life is swinging on a trapeze – sans…
  • MS Dilemma: My Body’s Depressed, But I’m Not

    Trevis Gleason
    14 Jul 2015 | 6:39 am
    Once a month for the past nine years, we’ve put out the question, “How’s your MS today?” Each time, we’ve taken advantage of this space to check in with ourselves, check out what others are experiencing, and check off our list of MS symptoms that are better, worse, or the same as the previous month. Here we are in July, more than halfway through the year, so it’s time to do it again. The scale we’ve been using to rate our symptoms is one I invented just for this purpose: the Life With Multiple Sclerosis Self-Evaluation Scale (LWM3S). It’s a simple, 1 to 10 scale in which:…
  • Ballroom Dance for Multiple Sclerosis? Why Not?

    Trevis Gleason
    10 Jul 2015 | 2:01 pm
    Shall we dance? Preliminary results of a recent study presented at the annual meeting of the Consortium of Multiple Sclerosis Centers in May indicate that “…ballroom dance can be a fun, social form of physical activity for people with MS that can result in improved motor performance, gait, endurance, and cognition.” Ballroom-style dancing has previously shown benefits in patients with Parkinson’s disease and Alzheimer’s disease. A small study published in Disability and Rehabilitation in April 2015 suggested that structured salsa lessons could improve physical activity,…
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    Maggsbunny

  • 23 Jul 2015 | 6:43 am

    Maggie
    23 Jul 2015 | 6:43 am
    The term started for mothers and miracles today, and I drove Vivi and I there myself, which is a big deal. Michael took my mom’s colt, which is currently living in our garage, to work so that Viv and I could use our car, which has the baby seat it. So I got up at eight, pulled the car out of the carport, got myself and Vivi’s stuff ready and then woke her at about twenty to nine. Quick nappy change and bottle, and we were ready to roll. Vivi enjoyed the class immensely. Probably the most she has enjoyed one to date. Especially the sensory play. She got a bowl of flour first. Had…
  • Celebrating the big 1

    Maggie
    21 Jul 2015 | 7:03 am
    Vivi Rosebud is officially one year old I felt so emotional on her birthday! No longer my tiny baby. Very quickly approaching toddlerhood. I am so, so thankful that she is doing so well. And that I’m doing all right. She has gone from a dainty little newborn of 2.52kg, to a bouncing, bonnie little girl of 10.3kg We celebrated her birthday the whole of Friday and Saturday! On Friday morning, her and I went off to our mothers/ babies group. She got really nice presents, including a dolly pram from Aunty Candy and Luke, a pop-up Little Red Riding hood book and pooh bear plate/bowl/ cup set…
  • Countdown to one!

    Maggie
    8 Jul 2015 | 1:34 pm
    I can hardly believe it, but my baby girl is almost one. We’ve spent a whole year with this sweet, wonderful little person. I’m dismally behind on documenting her milestones but I did make a mental note of the first time she stood up against something on her own (30 June) Tonight she was standing against the couch, flinging her dad’s pj’s onto the carpet, the litte minx. She’s had a couple of nights of not being herself. Everyone still had pretty much their full quota of sleep, but she’s been going to bed later. She also introduced a strict lunch time nap…
  • 3 Jun 2015 | 1:58 pm

    Maggie
    3 Jun 2015 | 1:58 pm
    I wasn’t really planning on blogging, but Vivi Rose was so cute today she leaves me no choice Firstly, she said bye-bye to her daddy when he left for work after lunch, accompanied by a wave. Three times she said it. Then she said it to me later, when I did a pretend departure. And she said it to her grandparents when they left after their visit this evening. And called out an extra “Bye” after them as they went out the door She has also been saying num-num when she is eating but only if it something she likes. She’s been doing that for a couple of months. Then…
  • Time to pick up the ol’ blog…

    Maggie
    14 May 2015 | 7:50 am
    Bet everyone will be surprised to see a post from me in their blog feed reader. Haha. But yes, it is time to start blogging again. I am losing too many precious memories by not journaling. And blogging seems to be the best way for me to journal. For a lot of us I’m surprised I haven’t been blogging more, because it has been going really bad with my MS, and that is usually a trigger for me to blog. But the thing is, I have been feeling too bad to blog. It has taken till now for me to be able to type reasonably again. At a stage it was almost impossible, that’s how badly my…
 
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    Brass and Ivory: Life with MS and RA

  • Treatment for MS-Related Itching

    16 Jul 2015 | 6:47 am
    Pruritus in MS can be tricky to treat. If the itching is mild, treatment is usually unnecessary and the symptom often goes away on its own. If the itching is severe, prolonged, or disrupts your daily life, talk to your doctor about possible treatments.Since itchiness associated with MS is neurologic in origin, cortisone cream and other topical treatments are rarely helpful. There are some medications, however, which may be useful in diminishing the itch, including anticonvulsants (e.g. gabapentin, carbamazepine, phenytoin), antidepressants (e.g. amitriptyline, paroxetine, mirtazapine), and…
  • Itchiness as an MS Symptom

    16 Jul 2015 | 6:40 am
    When pruritus occurs as a symptom of multiple sclerosis, it is similar to other neurologic sensations - pins and needles, burning, stabbing, or tearing pain - known as dysesthesias. The itching with MS is often paroxysmal (coming on suddenly with great intensity) but temporary in nature and lasting anywhere from a couple of seconds to minutes. It can even seem to get worse the more you scratch.Heat triggers pruritus for some people with MS and for others, it seems to be related to movement or tactile stimulation. For some reason, the itching often occurs at night with an intensity that has…
  • Copay Assistance Programs, and More, Available to MS Patients

    11 Jul 2015 | 5:39 am
    Copay assistance programs can be blessings for patients who cannot afford to pay for prescribed medications despite insurance coverage. Frequently, drug manufacturers are able to provide financial help directly to patients in need. To access manufacturer-sponsored programs, visit the brand website for the MS drug which you have been prescribed.For patients who do not quality for manufacturer programs (perhaps due to insurance coverage through government programs such as Medicare), the following non-profit organizations offer additional help paying for medications. Some of these programs even…
  • Make the Most of Your Doctors' Visits

    9 Jul 2015 | 5:42 am
    Check out my latest slideshow on HealthCentral. Included are ten practical tips to making the most of your doctors' visits.Top 10 Things to Tell Your Doctor If You Have MS
  • Talking to Your Doctor About Family Planning and MS Drugs

    6 Jul 2015 | 8:57 am
    Some of the newer MS medications are contraindicated with pregnancy, including drugs that must be stopped for a period of time before a patient attempts to become pregnant, such as Aubagio or Gilenya. However, approximately half of all pregnancies are unintended, whether mistimed, unplanned, or unwanted, according to the CDC. So it is important to do some planning in advance to prepare yourself for the unexpected.Talking to Your DoctorNeurologists have much area to cover in a brief period of time during appointments. Family planning and reproduction are topics that likely do not rank in the…
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    A Short in the Cord

  • #ADA25, Stringy-thingies, and Complete Ignorance

    28 Jul 2015 | 2:51 pm
    Last Sunday (26 July 2015) was the 25th anniversary of the signing of the Americans with Disabilities Act, a civil-rights law that makes it illegal to discriminate against people with disabilities in housing, employment, transportation, public facilities, and telecommunications.As an advocate for increased awareness for disabilities at my fellowship (UUFN), I thought last Sunday would be a good day to have a conversation around the ADA during the Story for All Ages (aka the children’s story that I've mentioned before). So I started with a hunk of blue wax that has a stringy-thingy…
  • A Shot a Day

    13 Jul 2015 | 3:00 pm
    No, I'm not talking about medication or alcohol. While in Chicago for an MS bloggers forum, I was dreading the impending discussion about social media.  I will confess that I have a love/hate relationship with social media. Mostly hate.Years ago, I was an early adopter of technology and social media sites as part of my different jobs, which required me to stay current on computer technology trends. Back in the 90's, I was using the Internet before AOL launched a flat-rate campaign and crashed all its servers (remember busy signals and phone modems?). I was on Facebook before it…
  • There Are No Guarantees in Nature

    12 Jul 2015 | 11:36 am
    So the Bluebirds didn't win after all. While reporting that we had two eggs in our Eastern Bluebird nest, I said that there are NO guarantees in nature.  And today, I discovered that there are now NO eggs in the nest box.This is not the first time that we've discovered missing eggs.  In fact, about 55-80% of Eastern Bluebird nesting attempts fail (ref: http://www.sialis.org/predatorid.htm). As always, there is no evidence to explain what happened: no egg shell pieces, no flattened nest or grass areas, no footprints, no smoking gun. The nest box is mounted on a metal pole…
  • And the Winner of the Battle Box Is...

    10 Jul 2015 | 3:46 pm
    ... the Bluebirds.  Catbird demanding airspace rightsFor now, anyway. As of 10 July 15, the Eastern Bluebirds have two new eggs in the nest box that was the subject of a custody dispute explained in my last post.  (Although a Catbird has applied for ownership of the airspace on top of the box because it needs a lookout point.)Carolina WrenBut as we all know, there are no guarantees in nature. The Bluebirds still face threats to their nest and eggs from wrens and Evil House Sparrows. They have to dodge predators like owls and domestic cats. There is competition for food from…
  • Battle Box

    5 Jul 2015 | 8:23 pm
    Once upon a time, we had a peaceful backyard. (Cue the Disney fairy meadow music.) The Eastern Bluebirds had a successful brood in our Bluebird Nest Box and started on a second family; but, Evil European House Sparrows attacked the second nest, destroyed the eggs and chased out the Bluebirds (cue sound track from Psycho). In the US, Evil European House Sparrows are not native, are very destructive, and considered a pest. They are one bird species not protected by the Migratory Bird Treaty Act, so we Nest Watchers are allowed to interfere with their nest building and allowed to trap…
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    MS Trust Recent Story List

  • Beach wheelchairs

    27 Jul 2015 | 4:00 pm
    James Coke, who has primary progressive MS and who likes swimming in the sea, highlights the difficulty in finding beach wheelchairs in the UK and how the situation is better in Mallorca. Guardian Travelling and holidays
  • Personal care budgets

    26 Jul 2015 | 4:00 pm
    A woman with MS in Norfolk who has a personal care budget and the chief executive of a charity that helps people manage these funds talk about the benefits of the approach and the dangers of cuts to social care funding. Eastern Daily Press Individual budgets - A to Z of MS
  • Off-Patent Drugs Bill

    23 Jul 2015 | 4:00 pm
    A private members bill seeking to allow access to drugs off patent is going through parliament. A previous attempt before the election failed. This story focusses on a breast cancer treatment but treatment of MS is also briefly mentioned. Independent MS-SMART trial - investigating repurposing drugs for secondary progressive MS
  • Predictive factors for MS in CIS

    21 Jul 2015 | 4:00 pm
    Spanish research found that the number of lesions was the best indicator that someone with CIS would develop MS. Oligoclonal bands were a 'medium-impact prognostic factor' and gender and location of lesions less indicative. Disease modifying drug treatment extended the time before MS diagnosis. MSIF Clinically isolated syndrome (CIS) - A to Z of MS
  • Importance of location of lesions

    20 Jul 2015 | 4:00 pm
    A study using a high powered MRI found that lesions seen in the cerebral cortex (grey matter) were more associated with cognitive and physical symptoms than white matter lesions. Researchers suggest that the effect of treatments on reducing the formation of cortical lesions should be studied. MedPage Today Lesions - A to Z of MS
 
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    Wheelchair Kamikaze

  • Moments of Clarity – Repost

    The Wheelchair Kamikaze
    28 Jul 2015 | 9:25 pm
    (Sorry I've been scarce lately, been fighting a really bad case of the creeping cruds that has kept me in bed the last few weeks. Fever, no appetite, weakness, all on top of the progressive MS stuff. Needless to say, not much fun at all. Just started my second round of antibiotics, so I expect things will get better soon. In the meantime, lest you think I simply vanished into the ether, here's a favorite old Wheelchair Kamikaze post of mine, back from December 2009, when this blog was not yet one year old. Rereading this essay after all these years reminded me that I really need to get back…
  • Back from the NIH: Unfortunately, Nothing Dramatic to Report

    The Wheelchair Kamikaze
    5 Jul 2015 | 9:02 pm
    Well, I’m back from my sojourn to the nation’s capital in search of answers regarding my ever progressing and relentlessly stubborn illness. Sorry it’s taken so long to report back, but the trip left me pretty exhausted, and for the last week or so I just haven’t been myself. Oddly, I think I’ve been Ethel Merman, but that’ll have to be a subject for another blog post… On the evening of June 23, Karen and I packed ourselves into a rented wheelchair accessible van and hoofed it down to Bethesda, Maryland (just outside of Washington DC) for a visit to the National Institutes of…
  • I’m Off to the National Institutes Of Health…

    The Wheelchair Kamikaze
    22 Jun 2015 | 9:23 pm
    Just wanted to check in lest anybody think I vaporized or otherwise met with misfortune. I’ll have to keep this relatively short, as I’m scrambling to get ready to go to the National Institutes of Health (NIH) Clinical Center, in Bethesda Maryland. The NIH is the US government’s primary medical research organization, and they maintain a state-of-the-art clinical complex on a sprawling campus just outside of Washington DC. I’ve been seen by the doctors/researchers at the National Institutes of Health (NIH) three times since 2009, when I was part of an NIH study that sought to identify…
  • Recent Research on HSCT, the Stem Cell Therapy That May Soon Change the MS Treatment Landscape.

    The Wheelchair Kamikaze
    4 Jun 2015 | 9:22 pm
    (Please note: the following article is quite long. Though it covers a very important topic and I’ve tried to make it as accessible as possible, I’d suggest getting comfy and grabbing a nice beverage before diving in…) Over the last six months or so, there has been a wave of new and encouraging research published regarding HSCT (Hematopoietic Stem Cell Therapy) for the treatment of multiple sclerosis. HSCT is the type of stem cell therapy in which a patient’s existing immune system is completely eradicated through the use of powerful chemotherapy drugs and is then rebooted via an…
  • Attacked by a Three-Headed Beast

    The Wheelchair Kamikaze
    13 May 2015 | 6:20 pm
    When I first started writing Wheelchair Kamikaze back in 2009 I had very little idea of what these pages might eventually evolve into, but I did know that I didn’t want the blog to take the form of an illness diary, a simple journal of my MS symptoms and day-to-day experiences with the disease. Instead, I wanted to concentrate more on the emotional and perceptual impact of dealing with a progressive crippling disease, of being forced to slowly watch one’s body being consumed from within while trying not to lose one’s head in the process. I also thought the blog would be a good place to…
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    Life in Spite of MS Blog

  • 50 years old!! Life changing

    23 Jul 2015 | 9:43 pm
    I'm still a lot confused with symptoms and what to look for in a relapse. I'm off for an MRI on brain and spine and to compare them with last years.
  • Meet Kym Sellers!

    9 May 2015 | 7:36 pm
    Meet Kym Sellers - a local Cleveland, Ohio radio personality. Kym has always been a fighter, so fighting MS in order to help others, as well as herself, comes naturally.
  • Severe Onset MS

    7 May 2015 | 6:35 am
    Severe onset MS is when multiple sclerosis comes on suddenly with severe symptoms that can cause anything from blindness to paralysis. Can you come back from this type of MS? Read Breea's story
  • We have a...., NEW FORUM!

    29 Apr 2015 | 9:00 pm
    Sorry for shouting, but I'm very excited to announce our new forum - The Link II - right here, and there's a Chat Room! Yes. I kid you not. We've taken the steps to provide this resource for you, our most valued visitors. Share, Tweet, and Tell everyone you know that it's finally here! Just follow the link below to register and join. Once you're approved (a minor technicality) you'll be good to go. We've already added a few members from The Link (I) and hope they find their way here. Please Note: Your first 5 posts will need to be approved - (to make sure you're not a robot or spammer) - then…
  • We have a...., NEW FORUM!

    29 Apr 2015 | 9:00 pm
    Sorry for shouting, but I'm very excited to announce our new forum - The Link II - right here, and there's a Chat Room! Yes. I kid you not. We've taken the steps to provide this resource for you, our most valued visitors. Share, Tweet, and Tell everyone you know that it's finally here! Just follow the link below to register and join. Once you're approved (a minor technicality) you'll be good to go. We've already added a few members from The Link (I) and hope they find their way here. Please Note: Your first 5 posts will need to be approved - (to make sure you're not a robot or spammer) - then…
 
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    Multiple Sclerosis Research

  • NEDA-5: Neurofilaments

    Neuro Doc Gnanapavan
    4 Aug 2015 | 1:00 am
    NEDA or 'No Evidence of Disease Activity' currently uses 4 parameters that are routinely collected in contemporary clinical trials:Relapse activityDisability progressionMRI activityMRI atrophyNEDA-4NEDA has largely come into fruition with the introduction of highly active therapies, which for the first time allow us to achieve disease remission in MS. These therapies have set the benchmark, and as they grow in number so do our treatment expectations. And here starts the evolution in our definition of MS treatment strategies.The Holy Grail of MS treatment strategy will always be in my books…
  • Monitoring NEDA with Gd-enhanced MRI

    Gavin Giovannoni
    3 Aug 2015 | 11:41 pm
    How safe are frequent Gd-enhanced MRI scans? #MSBlog #MSResearch"The following communication from the FDA is worrying, it suggest that people who undergo frequent gadolinium-enhanced MRI accumulate gadolinium (gD) in the brain long after the last administration. At present it unknown whether this is harmful or not. I have asked Professor David Miller to advise on this as it is very relevant to monitoring MS. We use Gd in clinical trials and routine clinical practice to monitor for active disease. In future we may have to limit ourselves to T2 scans only and count new and enlarging T2 lesions…
  • Neuros are Monkeys when it comes to assessing cognitive problems

    MouseDoctor
    3 Aug 2015 | 11:00 pm
    Romero K, Shammi P, Feinstein A. Neurologists׳ accuracy in predicting cognitive impairment in multiple sclerosis. Mult Scler Relat Disord. 2015; 4:291-5.Cognitive impairment affects approximately 40-70% of MS patients. As management of MS typically begins with, and is co-ordinated by neurologists, they are often the first to raise concerns about a patient׳s cognitive functioning. However, it is not known how accurate the neurological examination is in identifying cognitive impairment. To this end, we conducted a retrospective chart review of 97 MS patients referred by neurologists for…
  • Is ageing a disease?

    Gavin Giovannoni
    3 Aug 2015 | 1:15 am
    DAY 2 OF SUMMER HOLIDAYS The debate about whether ageing is a  natural or physiological process is not trivial. For Pharma to develop drugs to treat ageing they need it to be classed as a disease. Why? MoneyThird party payers only pay for treatments and the management of diseases and not for lifestyle issues. Is this important for MS? If a component of progressive MS is premature ageing then we want ageing to be a disease. This will create the incentives for drug development. Do you agree?
  • Dimethyl fumarate has a risk of low blood white cell counts

    MouseDoctor
    2 Aug 2015 | 11:00 pm
    Khatri BO, Garland J, Berger J, Kramer J, Sershon L, Olapo T, Sesing J, Dukic M, Rehn E The effect of dimethyl fumarate (Tecfidera™) on lymphocyte counts: A potential contributor to progressive multifocal leukoencephalopathy risk. Mult Scler Relat Disord. 2015; 4:377-9. doi: 10.1016/j.msard.2015.05.003. Epub 2015 May 14.Dimethyl fumarate (Tecfidera™) is an effective therapy for relapsing forms of multiple sclerosis (MS). Our study suggests that this drug may have immunosuppressive properties evidenced by significant sustained reduction in CD8 lymphocyte counts and, to a lesser…
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